রবিবার, ৩১ মার্চ, ২০১৩

Turkey, Israel to work out compensation

ANKARA, Turkey (AP) ? Turkey's deputy prime minister says Turkish and Israeli officials will meet next week to work out the amount of compensation to be paid to the victims of a raid on a Gaza-bound flotilla that killed eight Turks and a Turkish-American in 2010.

Israel apologized for the botched raid last week and agreed to compensate the injured and relatives of the dead.

Turkey accepted the apology but said it wanted to ensure the victims were compensated and Israel remained committed to the easing of restrictions of goods entering Gaza before restoring full diplomatic relations.

Bulent Arinc said Friday an Israeli delegation will travel to Turkey next week. He says the amount of compensation to be requested will be worked out in consultation with experts and the families' lawyers.

Source: http://news.yahoo.com/turkey-israel-compensation-112455422.html

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Austrian police chase herd of cattle through town

VIENNA (AP) ? Austrian police and firefighters have taken on the role of urban cowboys in a two-day round-up of a herd of cattle that broke out of a fenced-off pasture and decided to go into town.

A police statement says the 43 steers defied attempts by police and volunteer firefighters to recapture them after wandering off Thursday and heading toward the Upper Austrian town of Freistadt. After being chased away from the railway station, they endangered motorists by stampeding onto a two-lane highway before running into a town suburb.

Two firefighters who tried to stop them were injured and needed hospital treatment.

The statement says 18 of the animals remain on the loose Friday. The rest have been corralled or tranquilized.

Source: http://news.yahoo.com/austrian-police-chase-herd-cattle-town-120729765.html

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শনিবার, ৩০ মার্চ, ২০১৩

Cell reprogramming during liver regeneration

Friday, March 29, 2013

During embryonic development, animals generate many different types of cells, each with a distinct function and identity.

"Although the identities of these cells remain stable under normal conditions, some cells can be persuaded to take on new identities, through reprogramming," says Ben Stanger, MD, PhD, assistant professor of Medicine in the Division of Gastroenterology at the Perelman School of Medicine, University of Pennsylvania.

Researchers have been able to reprogram cells experimentally, but few have shown that cells can change their identities under normal physiological conditions in the body, particularly in mammals.

In the cover article of this month's issue of Genes and Development, Stanger, PhD candidate Kilangsungla Yanger, Yiwei Zong, PhD, and their colleagues, did just that in the liver of a mouse. Stanger is also an investigator in the Abramson Family Cancer Research Institute and the Department of Cell and Developmental Biology.

The adult liver contains two major cell types ? hepatocytes and biliary cells ? that differ dramatically in appearance and function. Hepatocytes are the main cell type in the liver, where they synthesize proteins and other macromolecules, and detoxify toxic substances. Biliary cells, on the other hand, line the bile ducts, which carry bile from the liver to the small intestine to help digest fats.

Using a sensitive method to tag and track how cells develop and differentiate, the researchers found that conditional expression of an activated Notch1 gene converted hepatocytes into biliary cells. Notch is an important receptor for relaying signals to tell cells how to develop.

What's more, after the researchers injured liver cells with a variety of toxins to stimulate wound healing, they found that over two to three weeks hepatocytes activated a biliary cell program on their own, acquiring the shape and function of biliary cells. These changes were dependent on the activation of endogenous Notch signaling.

"This is direct evidence that cells can be converted from one mature cell type to another in a live animal, as part of a normal response to injury," says Stanger. "We think that augmenting pre-existing cell reprogramming relationships may be another way to engineer cells for the treatment of diseases in which there are not enough bile ducts, such as cholestasis."

###

University of Pennsylvania School of Medicine: http://www.uphs.upenn.edu/news/

Thanks to University of Pennsylvania School of Medicine for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127525/Cell_reprogramming_during_liver_regeneration

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Why We Write | The RANT

Typewriter and gun

Thursday, 12:40pm
Reno, NV
?I write because I cannot NOT write.? (Charlotte Bronte)

Howdy?

I want to cover three important things today.

Important Thing #1: Very exciting news this morning: My first Kindle ebook (?The Entrepreneur?s Guide To Getting Your Shit Together?) elbowed its way into best-seller territory on Amazon in less than half a day. It?s #4 on the ?entrepreneur? books-for-sale chart, with a bullet, and surging on the ?business? charts (in the top 35).

This is like watching your latest album climb the Billboard rankings. I labored over the book (with superb editing help from our pal David ?Flashman? Raybould) for many months, whipping it into shape and waiting for the right moment to dive into the wonderful new world of self-publishing that has just hit the Big Turning Point.

Now, it?s up to the reading public to decide if it?s worthwhile or not. A little scary, a little thrilling, a lot of fun for a writer who has craved being in control of publishing my own stuff, in my own damn way, for most of my life.

And, as satisfying as it is to read the great buzz-comments on the Amazon page (and in social media) for this new tome? it?s even more energizing to have finally busted my cherry in digital publishing. This first book took a while to finish and launched. The next one will follow blazingly quick, and there are even more in the hopper.

If you are so inclined, you can check out a free preview of the book (or even, gasp, buy it) here.

Leave a comment, too. And hit the ?share? button on the page. The tome is getting rave reviews, which makes sense since it?s a lovingly-revised compilation of my best Rant newsletters (which I mailed to subscribers for 6 amazing years). This is time-tested stuff, the best ?here?s what Carlton?s been teaching all these years? resource possible.

Hope you enjoy it, if you buy it. Hope you stay awake all night thinking about it if you don?t buy it, and feel compelled to buy it first thing in the morning. Cuz it?s damn cheap as a digital book, and you really SHOULD own it. (And yes, we?ll be offering a paperback version down the road, but this digital version is what you need right now.)

Important Thing #2:?I now know much about self-publishing ebooks that was a mystery to me before.

For example? the publishing industry is in complete upheaval now. The tipping point was last summer, when Amazon introduced it?s ?so easy an idiot can do it? self-publishing model for Kindle (and other e-reading devices)? and it turned out to actually BE just that easy to do.

This was a huge blow to the traditional publishers. Much like the revolution in digital music-sharing spelled big-time trouble to the entrenched old-school music industry. At first there was denial, then disbelief, and finally much gnashing of teeth and rending of clothes as it became crystal clear that the Publishing Game had changed permanently and dramatically.

Now, I?ve dealt a bit with traditional publishers. The old model sucked for writers like me, because there were huge roadblocks on the way to getting a book produced and put on shelves in bookstores? including agents who were assholes, publishers who hated anything outside of their comfort zone, and a sales process rigged like a back-alley craps game. (My favorite line about gambling: ?If you look around the table and you don?t know who the sucker is? then you?re the sucker.?)

I was given the fisheye by so-called ?publishing professionals? who assured me a deal was in the works, if only I changed everything funny and outrageous and important in my writing. Oh, and they?d charge $20 for my book, and give me (maybe) 90 cents of that, down the road after the accountants had cooked the books.

Traditional publishers mocked ebooks, smug in their surety of how things would never change. They were slow to accept even Kindle?s open-armed invitation to make digital books more inviting.

I have zero sympathy for them now that ebooks are outselling ?real? books (where trees must die so they can be printed)? and especially now that those agents are increasingly out of a job, and the publisher mucky-mucks are looking at early retirement now that ANYBODY can self-publish on Amazon? and enjoy a level playing field amongst other authors. Which is something the trad pub folks just hate.

And they can?t even mock self-publishers anymore, after Amazon bought Create Space, which prints your book, on demand, for a couple of bucks, and ships it for you. No need to pre-order a print run (or store boxes of your damn book in the garage). You just do the writing, and they take care of everything else. You make a sale, they print ?er up and ship. And you collect your moolah.

Plus, if you really have your little heart set on seeing your tome on a shelf at Barnes & Noble, they can help you get that done, too.

All this revolution has all taken place just in the past year or so. Ebooks have been doing well for a while, but with the recent smoothing-out of the process (making it truly brain-dead simple to plunder the vast market share that Amazon provides) and the sheer volume of ebook reading devices (including your mobile arsenal) now out there? it?s officially a brand-new world of sizzling opportunity for writers.

Now, there are numerous entrepreneurs offering you advice and insight on using these new powers of self-publishing, and you can hook up with them if you like.

However, this ain?t brain surgery. You really can figure out almost everything on your own. I opted to have a colleague (the very tech-savvy Lawton Chiles) help me finish the formatting, and get this first book actually up on Amazon? and it was an excellent small investment that sped up the process hugely. I also paid my primo designer pal Rick Allen to do the cover. All optional, all at extra ?(but very reasonable) cost? and all worth it, because it shortcut the process and assured the best possible finished book.

So I?m happy.

And you should be happy, too. If you have a book cooking inside you, or even if you just have an idea for a book? there is now a functional, efficient and profit friendly vehicle for you to quickly create a digital book that can literally be ready for purchase overnight. (And you get to KEEP most of the sale, instead of getting crumbs from a trad publisher.)

Entrepreneurs are especially getting hip to the wild opportunities this revolution has created. Short books that introduce you to the market can be offered for free or a couple of bucks. You can release material in serial form, so a new chapter appears once a week (just like magazines used to offer novels chapter by chapter in subsequent issues). You can choose to release an audio book, or a series of podcasts, or ? hell ? you can re-invent the entire CONCEPT of what a ?book? is, and see if the world likes it.

We are in the early days of a self-publishing Brave New World that is so exciting for authors and wannabe-authors I get teary just considering where it might go.

Which leads us to the last point?

Important Thing #3:?When I was a kid, I enjoyed both writing short science fiction stories and graphic novels of cartoons in a long-story format. It was immature stuff, but it was edgy and entertaining.

My audience consisted solely of my pals, a few teachers who caught me drawing during class, and occasionally a stranger who?d borrowed a mimeographed copy somewhere. I didn?t really care ? I wasn?t writing for an audience, I was writing for the pure joy of creating something from nothing. I?ve always been a storyteller, and writing them out (sometimes with accompanying illustrations) was a thrill in and of itself.

I was almost embarrassed to have anyone else see these efforts. Their praise made me wince (I?ve been a shy dude forever), and their criticism broke my heart (usually because it was so far off-base and irrelevant).

I don?t believe I would have pursued getting any of that early stuff published, even if it was possible. It was my training period, in a way. I was self-aware enough to know it was early-stage stuff, not a final product.

However? just knowing that I COULD publish it would have re-focused my energies ten-fold. What a trip, to decide on my own when I was ready to release my stuff into the world.?Not when some publisher decided. When I decided.

I got a taste of wider readership in high school, when I took journalism (wanting to earn a spot writing for the Teepee Times sports page)? and the teacher caught me doodling and ordered me to do a weekly cartoon on the editorial page instead. I was terrified, especially to be working in ink for the first time (pencils have erasers), and to have my drawings and humor laid out bare and vulnerable in front of God and everybody like that. Every week.

I survived for two seasons. There was no credible celebrity involved, either ? I had to play it safe in the newspaper, and the other kids just took it for granted that another dumb Carlton ?toon would be in the weekly issue. No biggie. One transfer junior from La Habra (tough school) offered me $5 to draw a grinning demon on his notebook, but otherwise my high school ?career? as a cartoonist was uneventful.

Then, the same thing happened in college. I happened to meet the editor of the university daily, who demanded that I do a weekly cartoon? and he didn?t care what I did with it. That got me reinvested, and I drew edgy, weird stuff that did get me a little notice. Decades later, I occasionally still get a nod from someone who remembers my strip fondly.

This was the same period of time when Doonesbury was just making waves, and other ?underground? comix were getting noticed. But I had no idea how to go further with the career, so I just stopped.

The ?bug? for being published, however, had been planted.

When I first met Gary Halbert, one big thing we had in common was a reverence for the ?classic? age of self-publishing back in the 1950s. A nobody like Hugh Hefner could scrape together $500 and enter a crowded magazine market doing most of the writing (he was also a cartoonist, remember)? and, if his stuff stood out from the pack, he might create a little empire. The field was wide open. (Underground comix ? which are now mainstream ? went the same route.)

But traditional publishing remained a closed game, dominated by big-name authors and taste-making mavens who decided what America could and couldn?t read en mass. Gary?s way around that was to publish his own newsletter (which you can peruse at www. thegaryhalbertletter.com), mailed monthly to subscribers. I took the same route with my direct-to-consumer Marketing Rebel Rant newsletters.

It was freaking exhilarating to write, design, print and mail my own publication. The audience was still small (it cost a cool grand back then to be a subscriber to the Rant for a year), but large enough to support my speaking career by ensuring most events would have at least a handful of supporters egging on the crowds.

We still self-publish my first course/book, ?Kick-Ass Copywriting Secrets of a Marketing Rebel?, and the Simple Writing System. We have a printer back east who binds and ships the packages (along with whatever CDs or DVDs are included).

But, again, the audience for these are whoever I can entice into my world through my blog, or via a speaking engagement. That ensures a healthy, but relatively segmented base.

So, when I caught wind of what Amazon was doing with the Kindle store, I perked up fast. This is a global market we?re talking about here, and Amazon is the 600-pound gorilla dominating the process.

Yes, allowing ?just any bozo with a manuscript? to self-publish and be available on their world-wide virtual bookshelves may lead to a certain amount of chaos. Some prospects will be overwhelmed with the choices. Some undeserving books will catch fire, while better ones sink into obscurity.

The bits of marketing you are allowed on your sales page are critical to your self-published dreams of grandeur. Just like every other marketplace in the universe.

However, with the interactive opportunities also available? comments, testimonials, ?buyers also bought? lists of robot-guessed stuff you might also want to buy, sharing in social media, etc? I see excellent chances for quality stuff to stay high on the charts for very long periods.

You aren?t dependent on a trad publisher dripping your book out to a few big-city bookstores? or on your ability to generate PR by going on endless author tours (and maybe snagging a desultory 2-minute slot on some foul-mouthed radio or cable chat show)? or on the sodden criticism of some unqualified reviewer in the New York Times (or Beaverton Gazette).

All the obstacles to producing and getting your book in front of a wide audience have now been obliterated.

O. Blit. Erated.

I was excited when the Web marketplace really got going a decade ago, and I?m a Net Junkie for sure. Modern tech changed my world view and my lifestyle habits. I?m fully wired, dude.

However? this publishing revolution rivals all the recent tech innovations put together.

This ain?t your father?s blog. This ain?t your grandfather?s hard-cover trilogy.

Nope.

What we got here is a stunning opportunity for the Little Author to beat up the Big Authors, in heroic fashion.

Self-publishing will change your life in ways none of us can yet imagine. (The TED talks on this subject are expanding exponentially.)

For those of us who?ve been hoping for fresh audiences, it?s paradise. Yet another thrill ride aimed right at entrepreneurs.

Now, go buy my book already.?

Stay frosty,

John

P.S. If you want to contact Rick, my designer? or Lawton, who helped get the book formatted and looking good on all devices? or Flashman, who is a primo copywriter and brilliant editor? just email my long-suffering assistant Diane at consult@john-carlton.com and ask for their contact info.

I only work with the best, and this team is spectacular at what they do. And, they?re open to working with you?

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Source: http://www.john-carlton.com/2013/03/why-we-write/

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Obese airline passengers should pay extra, economist says

(Reuters) - Airlines should charge obese passengers more, a Norwegian economist has suggested, arguing that "pay as you weigh" pricing would bring health, financial and environmental dividends.

Bharat Bhatta, an associate professor at Sogn og Fjordane University College, said that airlines should follow other transport sectors and charge by space and weight.

"To the degree that passengers lose weight and therefore reduce fares, the savings that result are net benefits to the passengers," Bhatta wrote this week in the Journal of Revenue and Pricing Management.

"As a plane of a given make and model can accommodate more lightweight passengers, it may also reward airlines" and reduce the use of environmentally costly fuel.

Bhatta put together three models for what he called "pay as you weigh airline pricing."

The first would charge passengers according to how much they and their baggage weighed. It would set a rate for pounds (kg) per passenger so that someone weighing 130 pounds (59 kg) would pay half the fare of 260-pound (118-kg) person.

A second model would use a fixed base rate, with an extra charge for heavier passengers to cover the extra costs. Under this option, every passenger would have a different fare.

Bhatta's preferred option was the third, where the same fare would be charged if a passenger was of average weight. A discount or extra charge would be used if the passenger was above or below a certain limit.

That would lead to three kinds of fares - high, average and low, Bhatta said.

Airlines have grappled for years with how to deal with larger passengers as waistlines have steadily expanded. Such carriers as Air France and Southwest Airlines allow overweight passengers to buy extra seats and get a refund on them.

Asked about charging heavier passengers extra, Southwest spokesman Chris Mainz said: "We have our own policies in place and don't anticipate changing those."

United Air Lines Inc requires passengers who cannot fit comfortably into a single seat to buy another one. A spokeswoman said the carrier would not discuss "future pricing."

About two-thirds of U.S. adults are obese or overweight.

In a 2010 online survey for the travel website Skyscanner (www.skyscanner.net), 76 percent of travelers said airlines should charge overweight passengers more if they needed an extra seat.

(Reporting by Ian Simpson; editing by Andrew Hay)

Source: http://news.yahoo.com/obese-airline-passengers-pay-extra-economist-says-221406056--finance.html

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শুক্রবার, ২৯ মার্চ, ২০১৩

North Korea turns up volume by silencing final military hotline

What happens now?

By Robert Marquand,?Staff writer / March 27, 2013

South Korean army soldiers patrol along a barbed-wire fence near the border village of Panmunjom in Paju, South Korea, Wednesday. North Korea said Wednesday that it had cut off a key military hotline with South Korea that allows cross border travel to a jointly run industrial complex in the North.

Ahn Young-joon/AP

Enlarge

North Korea's edgy game of war talk continued?at ever higher volumes today with the announcement that it will cut off the last military hotline with South Korea.

Skip to next paragraph Robert Marquand

Staff writer

Over the past three decades, Robert Marquand has reported on a wide variety of subjects for?The Christian Science Monitor, including American education reform,?the wars in the Balkans, the Supreme Court, South Asian politics, and the oft-cited "rise of China." In the past 15 years he has served as the Monitor's bureau chief in Paris, Beijing, and New Delhi.?

Recent posts

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?Under the situation where a war may break out any moment, there is no need to keep North-South military communications,? said the regime, according to the Korean Central News Agency in Pyongyang.

The severed line of communication comes as the North, under young and new President Kim Jong-un, has said it is moving into its highest military alert status and has threatened to target Hawaii and Guam with rockets, after last month conducting its third nuclear test.?

The escalating rhetoric has brought a new agreement between US and South Korean officials that would dictate military action should the North cross the border, shell islands, or harm shipping in the kind of low-level actions Pyongyang has attempted in recent years.?

US military officials called the North Korean statement ?bellicose.??Many have expressed doubt that North Korea?s rockets have the range to reach US bases in Guam and Hawaii, but a few, including the?editor of Jane?s Defense Weekly, estimated they could reach US military bases in Japan, according to USA Today.?

Yesterday the small, poor state that is anchored by devotion to the Kim family dynasty, and is now nearly entirely dependent on China for basic sustenance but has also devoted considerable resources to its military, repeated a longstanding threat to turn Seoul into a ?sea of fire,? among other similarly colorful threats.

Earlier this year, the North said it would no longer answer?a hotline at the Demilitarized Zone. The hotline that the country is now threatening to shut down linked the two Koreas at the?Kaesong industrial park, created in the North during the warming winds of unification in the 2000s. The economic complex has long been a symbol of the potential for North-South cooperation.?

The New York Times today notes the North?s threat on the hotline follows comments from?Park Geun-hye,?the newly elected president of South Korea, that North Korea needed to end its nuclear threats in order to gain better traction with the South:

?If North Korea provokes or does things that harm peace, we must make sure that it gets nothing but will pay the price, while if it keeps its promises, the South should do the same,? she said during a briefing from her government?s top diplomats and North Korea policy-makers. ?Without rushing and in the same way we would lay one brick after another, we must develop South-North relations step by step, based on trust, and create sustainable peace.?

Scott Snyder of the Council on Foreign Relations in Washington, a veteran Korea watcher once based in Seoul, tells The Christian Science Monitor that Pyongyang's main grievance appears to be recent UN sanctions targeted at the North.

Mr. Snyder argues that the meaning of the North?s sudden blustery behavior will only become clearer ?once the question of the consolidation of [Kim Jong-un?s] power becomes clearer.?

Agence France-Presse today said that a significant meeting among party elites and power brokers in the closed world of Pyongyang is about to take place.

"They will discuss how to handle the nuclear issue, inter-Korean relations and North Korea's long-standing demand for a peace treaty with the United States," Professor Yang Moo-jin of the University of North Korean Studies in Seoul told AFP.

Comparisons between the new Kim and his grandfather, Kim Il-sung, the patriarch of North Korea, are flowing freely, since there is a resemblance between the two. But Snyder notes that too little is yet known of the young Kim, who took over from his father Kim Jong-il last year, and that his youth is not necessarily a plus in such a high-stakes game.

?Right now the song is the same, but the volume is a lot louder. We don?t know his risk tolerance yet ? does he understand the game he is playing??

The US-South Korea military agreement follows a recent scrapping by the North of the historic legal armistice that effectively ended the Korean war in the 1950s. It came on the anniversary of the infamous sinking of the Choenan Navy vessel in 2010, which resulted in the deaths of 46 South Korean sailors, something that has had powerful emotional resonance in the South. (The Choenan was raised from the ocean floor, and forensics by the South claim the vessel was torpedoed by the North, something the North denies.)?

USA Today quotes an Asia watcher who feels the key to dealing with Pyongyang runs through Beijing:

US diplomats should talk to their Chinese counterparts and say, "Your ally North Korea is acting in a very belligerent and destabilizing way," said [Richard] Bush, who heads the Brookings Institution Center for Northeast Asian Policy Studies. "They're acting in ways that are contrary to the principles you [China] have laid out. The situation is somewhat dangerous. You need to restrain your ally."

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/_YEoSdvzQGU/North-Korea-turns-up-volume-by-silencing-final-military-hotline

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বৃহস্পতিবার, ২৮ মার্চ, ২০১৩

Rapper Gucci Mane denied bond in assault case

ATLANTA (AP) ? Gucci Mane has been denied bond on charges stemming from a fan's accusation that the rapper hit him in the head with a champagne bottle at an Atlanta nightclub.

A fan says the rapper, whose real name is Radric Davis, hit him in the club's V.I.P. area March 16 while he tried to take a picture with Gucci Mane. The fan, James Lettley, says he needed 10 stitches.

Davis was in custody on a charge of aggravated assault with a weapon and appeared in court Wednesday.

The rapper's attorney, Drew Findling, tells WSB-TV (http://bit.ly/XdhFoP ) that Davis' criminal history made it difficult for a judge to set bond. Fulton County jail records show Davis has been arrested 10 times since 2005.

Source: http://news.yahoo.com/rapper-gucci-mane-denied-bond-assault-case-131949635.html

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Chillingo goes all-in with Android - Endless Road, He-Man, and more on the way

One of my favorite mobile game publishers, Chillingo, was at GDC 2013 and we got to catch up with them and hear about all of the awesome titles that are coming to Android. Some are already out, like Parking Mania and Contre Jour, but others like He-Man, Puzzle Craft, and Endless Road are on the way, and others still like Catapult King just came out. We only got to try out a few of these, but Chillingo's catalog is really impressive, and it will be great to see more of their stuff hitting Google Play this year. 

What are your favorite Chillingo games? Any other publisher that you have a particular fondness for? 



Source: http://feedproxy.google.com/~r/androidcentral/~3/1m8GBb5lg1A/story01.htm

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Obama appoints first woman Secret Service director

By Tabassum Zakaria and Steve Holland

WASHINGTON (Reuters) - President Barack Obama on Tuesday chose veteran agent Julia Pierson as Secret Service director, the first woman to lead the male-dominated agency, a year after its reputation was tarnished by a scandal involving agents and prostitutes in Colombia.

Pierson will replace Mark Sullivan, who retired in February and was in charge during the Colombia scandal - one of the worst in the agency's history.

The Secret Service has been criticized for having an insular, male-dominated culture, and Pierson's appointment also comes as Obama fends off criticism that his second-term picks for high-level posts have not included enough women and minority candidates.

Pierson, a native of Florida, is currently chief of staff at the Secret Service and began her career as a special agent with the Miami field office in 1983. The director's position does not require confirmation by the U.S. Senate.

"Julia is eminently qualified to lead the agency that not only safeguards Americans at major events and secures our financial system, but also protects our leaders and our first families, including my own," Obama said in a statement.

Starting in 1988, Pierson served four years with the Presidential Protective Division, and she became deputy assistant director of the Office of Protective Operations in 2005.

The Secret Service has been trying to rebuild its image after the April 2012 scandal when agency employees in Cartagena ahead of a visit by Obama took prostitutes to their hotel rooms.

It led to an official investigation that concluded that the president's safety had not been compromised, but the scandal was a big embarrassment for the agency.

A dozen Secret Service employees were accused of misconduct, and at least seven of them have left the agency.

Sullivan apologized to Congress last year for the episode, which he said reflected poor decisions by agents and was not representative of the agency's culture. A new code of conduct was implemented banning alcohol use within 10 hours of duty and patronizing "non-reputable" establishments.

"During the Colombia prostitution scandal, the Secret Service lost the trust of many Americans, and failed to live up to the high expectations placed on it," Republican Senator Chuck Grassley said on Tuesday.

"Ms. Pierson has a lot of work ahead of her to create a culture that respects the important job the agency is tasked with. I hope she succeeds in restoring lost credibility in the Secret Service."

In a statement Tuesday, Sullivan said Pierson would excel in the role. "I have known and worked with Julie for close to 30 years," Sullivan said about his successor. "This is a historic and exciting time for the Secret Service and I know Julie will do an outstanding job."

Pierson also received accolades from a key Democrat in Congress. Her appointment "is welcome news and a proud milestone," Senate Homeland Security Committee Chairman Tom Carper said in a statement.

Secret Service agents who know Pierson describe her as smart, experienced and even-keeled.

"Julie was selected because she is competent, and she has been around for 30 years and understands the service well," Ralph Basham, a former Secret Service director, told Reuters.

"It's exciting for the Secret Service. It's exciting to have a female named to that position. My daughter was a Secret Service agent, so it makes me very proud of the organization and proud of Julie for attaining that position," he said.

Law enforcement experts point out that Pierson will not be an anomaly in the broader federal law enforcement community - the heads of the Drug Enforcement Administration and U.S. Marshals Service are women.

SPECULATION OVER FORMER OFFICIAL

Sources had told Reuters earlier this month that Obama had chosen retired Secret Service official David O'Connor to head the agency. Former law enforcement agents said they had heard he had withdrawn his name, but that was not officially confirmed and O'Connor did not respond to several attempts to reach him.

The National Organization of Black Law Enforcement Executives, or NOBLE, had written to the White House in opposition to O'Connor.

O'Connor's name had cropped up in a long-running racial discrimination lawsuit after one email that used racially charged language was sent to him, but his attorney said he did not distribute it further.

Ronald Kessler, who has written a book about the Secret Service, said black agents applied pressure that went all the way up to Obama to torpedo O'Connor's appointment.

"My understanding is that Dave decided for personal reasons that he would withdraw his name," former Secret Service director Basham said. "I understand that it was he who decided to remove his name from consideration for the position."

(Additional reporting by Jeff Mason and Deborah Charles; Editing by Christopher Wilson and Cynthia Osterman)

Source: http://news.yahoo.com/obama-chooses-first-woman-secret-director-officials-185243781.html

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মঙ্গলবার, ২৬ মার্চ, ২০১৩

BlackBerry is getting ready to take over the screen of your Apple iPhone or Andr...

BlackBerry is getting ready to take over the screen of your Apple iPhone or Android handset in new commercials that will debut next week and feature what RIM CMO Frank Boulben describes as "real-time marketing" using a tactic called a takeover; the ?

Source: http://www.facebook.com/PhoneArena/posts/10151519470804598

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Normal brain activity linked to DNA damage

msnbc.com

By Charles Choi
LiveScience

Brain activity from experiences as common as exploring new locations surprisingly damages the noggin's DNA, hinting that such disruptions may be a key part of thinking, learning and memory, researchers say.

This damage normally heals rapidly, but abnormal proteins seen in Alzheimer's disease can increase this damage further, perhaps overwhelming the ability of brain cells to heal it. Further research into preventing this damage might help treat brain disorders, scientists added.

Explorer mice
Scientists analyzed young adult mice after they were placed into new, larger cages with different toys and odors that they were allowed to explore for two hours. They measured brain levels of a protein known as gamma-H2A.X, which accumulates when breaks occur in double-stranded molecules of DNA.

"DNA comes in double strands, and has the shape of a twisted ladder," said researcher Lennart Mucke, a neurologist and neuroscientist at the Gladstone Institute of Neurological Disease and the University of California at San Francisco. "Breaks in one strand, in one rail of the ladder, occur quite frequently, but breaking both takes quite a bit of damage and, in the brain, was thought to happen mostly in the context of disease." [10 Odd Facts About the Brain]

Unexpectedly, the researchers found such breaks also happened in the neurons of perfectly healthy mice, with up to six times more breaks in the neurons of explorer mice than in mice that remained in their home cages.

"Breaks of double strands of DNA seem to be a part of normal healthy brain activity," Mucke told LiveScience.

These DNA breaks occurred in various brain regions, especially in the dentate gyrus, an area necessary for spatial memory.

"It is both novel and intriguing, (the) team's finding that the accumulation and repair of DSBs (double-strand breaks) may be part of normal learning," said neuroscientist Fred Gage, of the Salk Institute, who did not take part in this study.

Mystery of DNA breaks
It remains uncertain why brain activity causes DNA breaks. Active neurons do generate DNA-damaging chemicals such as free radicals, but neurons in lab dishes did not have significantly fewer breaks when given antioxidant molecules that counteract free radicals.

Instead, the researchers suggest these breaks could actually help with the genetic activity linked with mental activity.

"We are now very excited to explore why neuron activity causes these breaks in DNA?? whether these breaks somehow facilitate the rapid conversion of genes into proteins involved in memory and learning and in processing all the information you take in when you do something new," Mucke said.

Many of the DNA breaks were fixed within 24 hours via DNA repair mechanisms in the cells. However, mice genetically engineered to produce a protein fragment known as amyloid beta, which accumulates in the brains of Alzheimer's patients, had more DNA breaks than normal in their brains, a problem that worsened during exploration.

Mice that produce human amyloid beta in their brains often have abnormal brain activity, including epileptic seizures, which can also occur in Alzheimer's patients. The researchers found that blocking this abnormal brain activity with the widely used anti-epileptic drug levetiracetam reduced the number of DNA breaks in the neurons of these mice.

"Levetiracetam is already an FDA-approved drug, and a very small clinical trial has already shown that it could provide some benefits in people with early-stage Alzheimer's," Mucke said. "These findings support the idea that the drug might be able to modify the disease by preventing the accumulation of DNA breaks that may promote its progress."

"We're in the process now of designing a larger-scale carefully controlled clinical trial to see if such a strategy is of benefit," Mucke added. "We encourage people to wait until this data becomes available and not jump the gun and start taking this drug when it hasn't been validated thoroughly yet."

The scientists also found that when mice lacked a protein known as tau, excess amyloid beta no longer caused more DNA breaks.

"Tau is intimately involved with Alzheimer's ? it seems to cooperate with amyloid beta," Mucke said. "In the absence of tau, amyloid beta doesn't seem to elicit detrimental effects. We're in the process of developing strategies to manipulate tau in Alzheimer's, and these findings encourage us to intensify and accelerate these efforts."

The scientists detailed their findings online Sunday in the journal Nature Neuroscience.

Follow?LiveScience @livescience, Facebook?and Google+. Original article on?LiveScience.com.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/29f7f79d/l/0Lscience0Bnbcnews0N0C0Inews0C20A130C0A30C250C174566860Enormal0Ebrain0Eactivity0Elinked0Eto0Edna0Edamage0Dlite/story01.htm

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Ogio's 13" Covert Shoulder Bag


If you're in the market for an inexpensive, lightweight, casual bag to carry your small laptop or tablet, and maybe a handful more than that, Ogio's 13" Covert Shoulder Bag ($69.99, direct) will get the job done. The? handles on top let you carry it like a briefcase, although the vertical design helps the bag maintain its somewhat grungy look.

Available in all black or heather gray with black accents (shown), this vertically designed bag holds a laptop up to 13 inches. The laptop section has adequate padding, quilted synthetic fabric, and a single zipper closure, but no security flap to hold your machine snug. In front of that section is another central area, which has a wide hinging mouth due to a long zipper that wraps around on three sides of the bag. Pull down the front, and you can easily see the bottom of the bag. Two mesh pouches, three pen slots, and two tiny square sleeves sewn into the right side round out this area.

At 14 by 9.5 by 2.5 inches (HWD), this bag hovers between being a small and medium size. It weighs a scant 1.4 pounds. The maximum volume, however, is only 550 cubic inches?in other words, it doesn't expand much, something I've seen in other slimline bags, such as the CODi UltraLite Laptop Backpack ($79.99, 3 stars). You can fit a tablet or small notebook, small miscellaneous items like a phone and some charging cords, maybe a book, but not much else. The bag works just fine when you know your load, but isn't well suited for someone routinely stuffing her bag with gym shoes, a packed lunch, or a water bottle. The back of the bag contains a quick access area (with no closure) where you can tuck away slightly bulky items in a pinch.

Something about the look of this bag screams 1980s or 90s street-wear, especially the heather gray model that has an almost denim-like texture. Were you to have slapped it over your shoulder and rocked on into The Palladium in its heyday, no one would have batted an eye. In any event, it's decidedly not a business bag.

A comparably sized bag that I personally love with more updated style sense is Crumpler's Arnold Heist Tablet Bag ($105, 4.5 stars), although it costs a $35 more.

Given the Covert is a vertical bag, two top handles let you carry it by hand when you need to take it off your shoulder, a nice touch. The padded shoulder strap is quite comfortable, and the adjusters for the strap length are exceptionally smooth.

Another great detail that's easy to miss: The very front of the bag has one more zippered pouch with a hidden slot for threading your headphones. As someone who's rather fussy about bag organization, this feature really speaks to me.

You'll do well with Ogio's 13" Convert Shoulder Bag under the following conditions: 1) the amount of stuff you carry day to day doesn't change dramatically; 2) you're into the urban street look; and 3) price matters. You'll end up spending an extra $30 or $40 to upgrade to something significantly better, but a lot of price-sensitive folks want to keep their bag budget well below the hundred-dollar mark.

If you are willing to spend more, get the Arnold Heist Tablet Bag. If you need a bag that can handle a larger laptop (up to 15 inches), Crumpler's Vegetable from Inside the Mountain ($145, 4.5 stars) is another personal favorite. The hundred-dollar Booq Mamba Daypack (4.5 stars)?which has a very straightforward and unassuming look?gets the job done at a lower price. Finally, if you have a very large laptop and are willing to spend a bit more money, consider the edgy all-black Chrome Citadel Laptop Bag ($190, 4 stars).

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/nvmoXQajI_o/0,2817,2417062,00.asp

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সোমবার, ২৫ মার্চ, ২০১৩

Money Monday: Are You Being Cheated at the Supermarket? | Black ...

Photo Credit: 401(K) 2013 via Flickr

Everyone is trying to take our money, from credit card companies to cable providers. But did you know your local grocery store could be cheating you every time you pay for groceries?

According to a report by ABC?s Good Morning America, consumers lose up to $2.5 billion dollars every year as a result of scanner errors. The most common problems involve scanners that are not programmed with the correct sales price information, scales that weigh and charge for the packaging in addition to the food, and stores that charge tax on non-taxable items.

In California, the state even took the unusual step of suing Safeway and its Vons stores for frequently overcharging customers. Similarly, in Los Angeles, Ralph?s Grocery Co. agreed to pay more than $1.1 million in civil penalties, costs and restitution to settle allegations that it overcharged customers on deli and other weighed food products.

In New York City, inspectors visiting 2000 city stores found price overcharges on one third of the products they tested. The problem was so bad that New York City Consumer Affairs commissioner Jonathan Mintz considered proposing legislation which would require grocery stores to pay customers 10 times the amount of the overcharged item.

Unfortunately, supermarket overcharges aren?t always insignificant. I, for instance, once purchased frozen dinners at a major Chicago grocery chain. The sale price was 5 for $10. Instead, I was charged full price on all five frozen meals, creating an overcharge of nearly $11 dollars.

With scanner errors being relatively common, there are a few ways to protect yourself. Keep a mental running account of your grocery tab as you shop. Better yet, bring along a calculator or smartphone to tally your total. If your tab doesn?t come close to the cashier?s result then you know you have a problem.

Alternatively, watch the checkout register like a hawk as your items are checked out. When in doubt, always check your receipt before you leave the store. Remember, many stores offer a ?right at the register or it?s free? policy. If you catch an overcharge you get the item for free.

BMWK ? Do you take the time to check your supermarket receipts? If you catch an error do you challenge it or let it slide?


About the author

Alonzo Peters is founder of MochaMoney.com, a personal finance website dedicated to helping Black America achieve financial independence.


Source: http://blackandmarriedwithkids.com/2013/03/money-monday-are-you-being-cheated-at-the-supermarket/

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In interview, Sandusky speaks of Paterno, witness

STATE COLLEGE, Pa. (AP) ? Jerry Sandusky said in interview excerpts broadcast Monday that a key witness against him misinterpreted him showering with a young boy in Penn State football team facilities more than a decade ago.

Sandusky told documentary filmmaker John Ziegler, in recordings played on NBC's "Today" show, that he does not understand how Mike McQueary concluded "that sex was going on" when he witnessed Sandusky showering with a boy in 2001.

"That would have been the last thing I would have thought about," Sandusky said during what Ziegler described as 3? hours of interviews. "I would have thought maybe fooling around or something like that."

McQueary, a graduate assistant in 2001, testified at trial that he heard "skin-on-skin smacking sound" and had no doubt he was witnessing anal sex.

The boy, identified as Victim 2 in court records, was not a witness at trial. A team of civil lawyers has said they are representing Victim 2 and posted online audio recordings of voicemails purportedly from Sandusky and left for the boy.

Sandusky also told Ziegler he was not sure whether head coach Joe Paterno, who was fired after Sandusky's November 2011 arrest, would have let him keep coaching if he suspected Sandusky was a pedophile. Sandusky was investigated by university police for a separate shower incident in 1998, but remained one of Paterno's top assistants through 1999.

"If he absolutely thought I was, I'd say no," Sandusky said. "If he had a suspicion, I don't know the answer to that."

Ziegler is working on a defense of Paterno. Wick Sollers, a Paterno family lawyer, said in a statement released Sunday that Sandusky had an opportunity to testify at trial but "chose not to do so."

Sandusky, 69, is serving a 30- to 60-year prison sentence after being convicted last year of 45 counts of child sexual abuse. He maintains his innocence and is pursuing appeals.

Source: http://news.yahoo.com/interview-sandusky-speaks-paterno-witness-120242280--spt.html

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Sanford-Burnham researchers unravel molecular roots of Down syndrome

Sanford-Burnham researchers unravel molecular roots of Down syndrome [ Back to EurekAlert! ] Public release date: 24-Mar-2013
[ | E-mail | Share Share ]

Contact: Heather Buschman, Ph.D.
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute

Sanford-Burnham researchers discover that the extra chromosome inherited in Down syndrome impairs learning and memory because it leads to low levels of SNX27 protein in the brain

LA JOLLA, Calif., March 24, 2013 What is it about the extra chromosome inherited in Down syndromechromosome 21that alters brain and body development? Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have new evidence that points to a protein called sorting nexin 27, or SNX27. SNX27 production is inhibited by a molecule encoded on chromosome 21. The study, published March 24 in Nature Medicine, shows that SNX27 is reduced in human Down syndrome brains. The extra copy of chromosome 21 means a person with Down syndrome produces less SNX27 protein, which in turn disrupts brain function. What's more, the researchers showed that restoring SNX27 in Down syndrome mice improves cognitive function and behavior.

"In the brain, SNX27 keeps certain receptors on the cell surfacereceptors that are necessary for neurons to fire properly," said Huaxi Xu, Ph.D., professor in Sanford-Burnham's Del E. Webb Neuroscience, Aging and Stem Cell Research Center and senior author of the study. "So, in Down syndrome, we believe lack of SNX27 is at least partly to blame for developmental and cognitive defects."

SNX27's role in brain function

Xu and colleagues started out working with mice that lack one copy of the snx27 gene. They noticed that the mice were mostly normal, but showed some significant defects in learning and memory. So the team dug deeper to determine why SNX27 would have that effect. They found that SNX27 helps keep glutamate receptors on the cell surface in neurons. Neurons need glutamate receptors in order to function correctly. With less SNX27, these mice had fewer active glutamate receptors and thus impaired learning and memory.

SNX27 levels are low in Down syndrome

Then the team got thinking about Down syndrome. The SNX27-deficient mice shared some characteristics with Down syndrome, so they took a look at human brains with the condition. This confirmed the clinical significance of their laboratory findingshumans with Down syndrome have significantly lower levels of SNX27.

Next, Xu and colleagues wondered how Down syndrome and low SNX27 are connectedcould the extra chromosome 21 encode something that affects SNX27 levels? They suspected microRNAs, small pieces of genetic material that don't code for protein, but instead influence the production of other genes. It turns out that chromosome 21 encodes one particular microRNA called miR-155. In human Down syndrome brains, the increase in miR-155 levels correlates almost perfectly with the decrease in SNX27.

Xu and his team concluded that, due to the extra chromosome 21 copy, the brains of people with Down syndrome produce extra miR-155, which by indirect means decreases SNX27 levels, in turn decreasing surface glutamate receptors. Through this mechanism, learning, memory, and behavior are impaired.

Restoring SNX27 function rescues Down syndrome mice

If people with Down syndrome simply have too much miR-155 or not enough SNX27, could that be fixed? The team explored this possibility. They used a noninfectious virus as a delivery vehicle to introduce new human SNX27 in the brains of Down syndrome mice.

"Everything goes back to normal after SNX27 treatment. It's amazingfirst we see the glutamate receptors come back, then memory deficit is repaired in our Down syndrome mice," said Xin Wang, a graduate student in Xu's lab and first author of the study. "Gene therapy of this sort hasn't really panned out in humans, however. So we're now screening small molecules to look for some that might increase SNX27 production or function in the brain."

###

This research was funded by the U.S. National Institutes of Health (National Institute on Aging grants R01AG038710, R01AG021173, R01AG030197, R01AG044420; National Institute of Neurological Disorders and Stroke grants R01NS046673, P30NS076411; Eunice Kennedy Shriver National Institute of Child Health & Human Development grant P01HD29587; National Institute of Environmental Health Sciences grant P01ES016738), Alzheimer's Association, American Health Assistance Foundation, National Natural Science Foundation of China, 973 Prophase Project, Natural Science Funds for Distinguished Young Scholar of Fujian Province, Program for New Century Excellent Talents in Universities, Fundamental Research Funds for the Central Universities, and Fok Ying Tung Education Foundation.

The study was co-authored by Xin Wang, Sanford-Burnham; Yingjun Zhao, Sanford-Burnham and Xiamen University; Xiaofei Zhang, Sanford-Burnham; Hedieh Badie, Sanford-Burnham; Ying Zhou, Sanford-Burnham; Yangling Mu, Salk Institute; Li Shen Loo, Institute of Molecular and Cell Biology, Singapore; Lei Cai, Institute of Molecular and Cell Biology, Singapore; Robert C. Thompson, Sanford-Burnham; Bo Yang, Sanford-Burnham; Yaomin Chen, Sanford-Burnham; Peter F. Johnson, National Cancer Institute-Frederick; Chengbiao Wu, University of California, San Diego; Guojun Bu, Xiamen University; William C. Mobley, University of California, San Diego; Dongxian Zhang, Sanford-Burnham; Fred H. Gage, Salk Institute; Barbara Ranscht, Sanford-Burnham; Yun-wu Zhang, Sanford-Burnham and Xiamen University; Stuart A. Lipton, Sanford-Burnham and University of California, San Diego; Wanjin Hong, Institute of Molecular and Cell Biology, Singapore and Xiamen University; and Huaxi Xu, Sanford-Burnham and Xiamen University.

About Sanford-Burnham Medical Research Institute

Sanford-Burnham Medical Research Institute is dedicated to discovering the fundamental molecular causes of disease and devising the innovative therapies of tomorrow. Sanford-Burnham takes a collaborative approach to medical research with major programs in cancer, neurodegeneration, diabetes, and infectious, inflammatory, and childhood diseases. The Institute is recognized for its National Cancer Institute-designated Cancer Center and expertise in drug discovery technologies. Sanford-Burnham is a nonprofit, independent institute that employs 1,200 scientists and staff in San Diego (La Jolla), California and Orlando (Lake Nona), Florida. For more information, visit us at sanfordburnham.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Sanford-Burnham researchers unravel molecular roots of Down syndrome [ Back to EurekAlert! ] Public release date: 24-Mar-2013
[ | E-mail | Share Share ]

Contact: Heather Buschman, Ph.D.
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute

Sanford-Burnham researchers discover that the extra chromosome inherited in Down syndrome impairs learning and memory because it leads to low levels of SNX27 protein in the brain

LA JOLLA, Calif., March 24, 2013 What is it about the extra chromosome inherited in Down syndromechromosome 21that alters brain and body development? Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have new evidence that points to a protein called sorting nexin 27, or SNX27. SNX27 production is inhibited by a molecule encoded on chromosome 21. The study, published March 24 in Nature Medicine, shows that SNX27 is reduced in human Down syndrome brains. The extra copy of chromosome 21 means a person with Down syndrome produces less SNX27 protein, which in turn disrupts brain function. What's more, the researchers showed that restoring SNX27 in Down syndrome mice improves cognitive function and behavior.

"In the brain, SNX27 keeps certain receptors on the cell surfacereceptors that are necessary for neurons to fire properly," said Huaxi Xu, Ph.D., professor in Sanford-Burnham's Del E. Webb Neuroscience, Aging and Stem Cell Research Center and senior author of the study. "So, in Down syndrome, we believe lack of SNX27 is at least partly to blame for developmental and cognitive defects."

SNX27's role in brain function

Xu and colleagues started out working with mice that lack one copy of the snx27 gene. They noticed that the mice were mostly normal, but showed some significant defects in learning and memory. So the team dug deeper to determine why SNX27 would have that effect. They found that SNX27 helps keep glutamate receptors on the cell surface in neurons. Neurons need glutamate receptors in order to function correctly. With less SNX27, these mice had fewer active glutamate receptors and thus impaired learning and memory.

SNX27 levels are low in Down syndrome

Then the team got thinking about Down syndrome. The SNX27-deficient mice shared some characteristics with Down syndrome, so they took a look at human brains with the condition. This confirmed the clinical significance of their laboratory findingshumans with Down syndrome have significantly lower levels of SNX27.

Next, Xu and colleagues wondered how Down syndrome and low SNX27 are connectedcould the extra chromosome 21 encode something that affects SNX27 levels? They suspected microRNAs, small pieces of genetic material that don't code for protein, but instead influence the production of other genes. It turns out that chromosome 21 encodes one particular microRNA called miR-155. In human Down syndrome brains, the increase in miR-155 levels correlates almost perfectly with the decrease in SNX27.

Xu and his team concluded that, due to the extra chromosome 21 copy, the brains of people with Down syndrome produce extra miR-155, which by indirect means decreases SNX27 levels, in turn decreasing surface glutamate receptors. Through this mechanism, learning, memory, and behavior are impaired.

Restoring SNX27 function rescues Down syndrome mice

If people with Down syndrome simply have too much miR-155 or not enough SNX27, could that be fixed? The team explored this possibility. They used a noninfectious virus as a delivery vehicle to introduce new human SNX27 in the brains of Down syndrome mice.

"Everything goes back to normal after SNX27 treatment. It's amazingfirst we see the glutamate receptors come back, then memory deficit is repaired in our Down syndrome mice," said Xin Wang, a graduate student in Xu's lab and first author of the study. "Gene therapy of this sort hasn't really panned out in humans, however. So we're now screening small molecules to look for some that might increase SNX27 production or function in the brain."

###

This research was funded by the U.S. National Institutes of Health (National Institute on Aging grants R01AG038710, R01AG021173, R01AG030197, R01AG044420; National Institute of Neurological Disorders and Stroke grants R01NS046673, P30NS076411; Eunice Kennedy Shriver National Institute of Child Health & Human Development grant P01HD29587; National Institute of Environmental Health Sciences grant P01ES016738), Alzheimer's Association, American Health Assistance Foundation, National Natural Science Foundation of China, 973 Prophase Project, Natural Science Funds for Distinguished Young Scholar of Fujian Province, Program for New Century Excellent Talents in Universities, Fundamental Research Funds for the Central Universities, and Fok Ying Tung Education Foundation.

The study was co-authored by Xin Wang, Sanford-Burnham; Yingjun Zhao, Sanford-Burnham and Xiamen University; Xiaofei Zhang, Sanford-Burnham; Hedieh Badie, Sanford-Burnham; Ying Zhou, Sanford-Burnham; Yangling Mu, Salk Institute; Li Shen Loo, Institute of Molecular and Cell Biology, Singapore; Lei Cai, Institute of Molecular and Cell Biology, Singapore; Robert C. Thompson, Sanford-Burnham; Bo Yang, Sanford-Burnham; Yaomin Chen, Sanford-Burnham; Peter F. Johnson, National Cancer Institute-Frederick; Chengbiao Wu, University of California, San Diego; Guojun Bu, Xiamen University; William C. Mobley, University of California, San Diego; Dongxian Zhang, Sanford-Burnham; Fred H. Gage, Salk Institute; Barbara Ranscht, Sanford-Burnham; Yun-wu Zhang, Sanford-Burnham and Xiamen University; Stuart A. Lipton, Sanford-Burnham and University of California, San Diego; Wanjin Hong, Institute of Molecular and Cell Biology, Singapore and Xiamen University; and Huaxi Xu, Sanford-Burnham and Xiamen University.

About Sanford-Burnham Medical Research Institute

Sanford-Burnham Medical Research Institute is dedicated to discovering the fundamental molecular causes of disease and devising the innovative therapies of tomorrow. Sanford-Burnham takes a collaborative approach to medical research with major programs in cancer, neurodegeneration, diabetes, and infectious, inflammatory, and childhood diseases. The Institute is recognized for its National Cancer Institute-designated Cancer Center and expertise in drug discovery technologies. Sanford-Burnham is a nonprofit, independent institute that employs 1,200 scientists and staff in San Diego (La Jolla), California and Orlando (Lake Nona), Florida. For more information, visit us at sanfordburnham.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/smri-sru032013.php

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রবিবার, ২৪ মার্চ, ২০১৩

The Cheapest and Easiest Way to File Your Taxes Online

April 15th will be here before you know it, and it's not like you've got complicated offshore holdings (or any holdings, for that matter), so why put off your taxes any longer than necessary? There are plenty of online services that let you do your taxes as soon as a you have your W-2. And unlike last year's debacle at the CPA, you won't be scolded for not putting on pants. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/iPDCXALlMYM/the-cheapest-and-easiest-way-to-file-your-taxes-online

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Internet Market Technology | Best Flash Games

Search engine optimisation can become the process of helping the amount and/or standard of guests to an online website from google for example Google, Yahoo plus Bing through all-natural or un-paid (natural or algorithmic) serps. Often termed as Search machines Optimization, SEO involves best positioning the site code, sites content, plus website architecture thus a website is simple due to not merely the main look machines plus convenient for individuals to read. What is a bit more, it involves backlink building plus connections towards the online ecosystem surrounding the website. PGMs affordable Search engine promoting are an advanced budgeting reported inside a website which really gains we lengthy expression, free results plus dramatically increases a exposure.

Seo isn?t because easy because it will appear because thoughtful planning plus implementation is required plus the main look motors promoting campaign which ought to be to be selected to get today involves complex processes involving intricate plus thorough off-site so on-site analysis and a continuing plus consistent repair plus monitoring to reassure oneself for you to get the largest results within the efforts. There are many items to consider whenever contriving a look engine optimisation campaign plus many of these factors which wish To be considered include coding to content to keyword analysis to squeeze page promoting plus anything which falls involving.

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Source: http://bunnibunni.com/moregames/internet-market-technology/

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Back injury sidelines Venus Williams at Sony Open

Venus Williams returns a shot from Kimiko Date-Krumm, of Japan, during the Sony Open tennis tournament, Thursday, March 21, 2013 in Key Biscayne, Fla. Williams won 7-6 (3) 3-6, 6-4. (AP Photo/Wilfredo Lee)

Venus Williams returns a shot from Kimiko Date-Krumm, of Japan, during the Sony Open tennis tournament, Thursday, March 21, 2013 in Key Biscayne, Fla. Williams won 7-6 (3) 3-6, 6-4. (AP Photo/Wilfredo Lee)

Venus Williams serves to Kimiko Date-Krumm, of Japan, during the Sony Open tennis tournament, Thursday, March 21, 2013, in Key Biscayne, Fla. (AP Photo/Wilfredo Lee)

Jo-Wilfried Tsonga, of France, serves to Viktor Troicki, of Serbia, during the Sony Open tennis tournament, Saturday, March 23, 2013, in Key Biscayne, Fla. (AP Photo/Lynne Sladky)

John Isner, of the United States, returns the ball to Ivan Dodig, of Croatia, during the Sony Open tennis tournament, Saturday, March 23, 2013, in Key Biscayne, Fla. (AP Photo/J Pat Carter)

Andy Murray, of Britain, cools off with an iced towel during a match against Bernard Tomic, of Australia, during the Sony Open tennis tournament, Saturday, March 23, 2013, in Key Biscayne, Fla. (AP Photo/Lynne Sladky)

(AP) ? A big match beckoned for Venus Williams on a court where she first hoisted the championship trophy 15 years ago.

Alas, on Saturday she wasn't up to any heavy lifting.

The three-time Key Biscayne champion withdrew from the Sony Open because of a lower back injury shortly before her third-round match against fellow American Sloane Stephens.

Williams, seeded 19th, was extended to three sets in the second round Thursday against Kimiko Date-Krumm. She said her back began to bother her Friday, and she decided after warming up that she couldn't play.

"It's really disappointing," she said. "But I have faced disappointments in my life and my career. It's not the first; probably not the last."

The cancellation cost the tournament the day's most appealing match, pitting a rising star against a seven-time Grand Slam champion. The 20-year-old Stephens upset Serena Williams at the Australian Open and is ranked a career-best 16th.

"I'm a little bummed, but I guess a win is a win," Stephens said. "On to the next round."

She'll play defending champion Agnieszka Radwanska on Monday, and could face a rematch against Serena Williams in the semifinals. Five-time champion Serena won her third-round match, overcoming a 3-love deficit in the first set to beat Ayumi Morita 6-3, 6-3.

"Definitely a little bit of a rough start," the No. 1-ranked Williams said. "It was good to get through this match."

Venus Williams said she hopes the back ailment won't prevent her from playing in her next scheduled tournament at Charleston, S.C., beginning April 1.

"That's always a concern, but I have dealt with injuries before in my whole career," she said. "I feel like also I know how to hopefully recover quickly from them."

The 32-year-old Williams hasn't beaten a top-10 opponent since August, and has played in just three tournaments this year. She lost in the third round at the Australian Open to Maria Sharapova, and was beaten by No. 109-ranked Olga Puchkova in the semifinals of the Brazil Tennis Cup last month.

Williams won the title in 1998, 1999 and 2001, and was appearing at Key Biscayne for the 14th time. Stephens found it difficult to imagine herself playing for so many years.

"Oh, man. That's crazy," she said. "I just turned 20, so I don't know. I mean, I hope. I mean, if I can I want to, but that's still really a long ways away for me."

Williams' injury was the second in two days to sideline a former Key Biscayne champion. Two-time winner Victoria Azarenka withdrew before her opening match Friday because of a right ankle injury.

On a sunny, humid afternoon, Sam Querrey won in his first match as the top-ranked American, rallying past Lukasz Kubot 4-6, 6-3, 6-3. The 20th-ranked Querrey this week moved ahead of No. 23 John Isner, who hit 25 aces and beat Ivan Dodig, 6-4, 5-7, 7-6 (5).

Isner has won his past five winner-take-all third-set tiebreakers.

"I really tend to play my best in a tiebreaker, for whatever reason," he said. "I wish I could sometimes play a little better outside of that."

Second-seeded Andy Murray needed only 56 minutes to beat Bernard Tomic 6-3, 6-1. The absence of Roger Federer and Rafael Nadal helps Murray's chances in the tournament, which he won in 2009.

"When you know they aren't going to be here, then it obviously changes things a little bit," Murray said. "For tennis it's way better if all of the top players are here. I think we have been very lucky the last few years especially that a lot of the top players have fulfilled their commitments to all of the big events. So it's going to happen from time to time, and it's unfortunate for this event that it happened here."

Tomic, who fell to 2-15 against top-10 opponents, drew jeers from the stadium crowd during his lackluster performance.

Radwanska, seeded fourth, lost serve seven times and needed nearly 2? hours to beat Magdalena Rybarikova 7-6 (5), 2-6, 6-3. No. 9 Caroline Wozniacki lost to wild card Garbine Muguruza of Spain, 6-2, 6-4.

Querrey lost his first service game but held the rest of the way and hit 12 aces against Kubot. The 25-year-old Querrey said being the top-ranked American has provided only a modest boost in confidence.

"Some days more than others," he said. "I never thought about it out there today. Haven't really thought about it much. Felt like another day out there to me. Nothing new."

Querrey won despite a lack of rest. He's staying near downtown Miami, site of a weekend electronic music festival.

"I'm not sleeping well because of this Ultra Festival going on," he said. "I could hear the bass, and strobe lights were shining in my hotel, so it's hard to sleep."

Isner said the festival hasn't bothered him.

"I can sleep through anything," he said. "I can sleep through a train wreck. Do not hear it, which is good."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-03-23-Key%20Biscayne/id-99130b6b12634fa2a283e59c7cd46d5f

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